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My marathon is at a higher elevation...what does this mean?

I remember when I signed up for my marathon 5 months ago reading something about elevation/oxygen levels effecting my marathon....
I am at sea level and my marathon is at 2200 feet:( I thought I had read I would be fine but there is a local coach who knows quite a bit about this who told my friend this could add 5min onto my time... sigh. that's a BUMMER!
but it makes sense....if there isn't as much oxygen in their air...and I haven't trained at that elevation it really could affect my performance.

Has anyone else trained at sea level then ran at an elevation of 1500 feet or more difference?